The risks are very low, but some women have experienced unwanted side effects when using Clindamycin phosphate. Minor ones include skin dryness, itching, redness, mild burning, or worsening of acne. Those effects will decrease with continued use of the medication.
If you experience blistering, severe burning/swelling of the skin, eye redness and watering (conjunctivitis), eyelid swelling, or skin discoloration, STOP the medication and tell your doctor immediately. Also, rarely this medication can cause discoloration of the skin. Dark-skinned people may notice a lightening in skin color in the area where you use this medication.
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First, clean the acne-affected area with a gentle soap and make sure it is completely dry. Apply a small amount of the clindamycin gel or lotion on the treated area, rubbing it in gently on the skin before bedtime.
If any side effect is experienced while using clindamycin lotion or gel, they should go away after stopping its use. Always contact your doctor if you experience any side effects. And call 911 or go to the ER if you experience any difficulty breathing, itchy rash, etc.
Clindamycin works by slowly stopping the growth of bacteria which contribute to the clogging of pores that lead to outbreaks. When treating acne, clindamycin works well when used in conjunction with benzoyl peroxide or retinoids like adapalene. Clindamycin does not exfoliate, so it might not unclog pores like BHAs (beta hydroxy acid) and AHS (alpha hydroxy acid) can.Clindamycin has anti-inflammatory benefits and works to keep skin radiant and fresh. Regular and consistent use of clindamycin should produce results in four to six weeks.
Products containing clindamycin are available by prescription and may be covered by insurance. At Nurx, we offer Clindamycin as a topical acne treatment with insurance or affordable out-of-pocket prices. Just answer a few questions and after reviewing your medical history a provider will prescribe Clindamycin, if appropriate. We'll deliver your medication straight to your door.
Clindamycin can interact with other medications, especially other antibiotics or antibacterial medications. It is best to consult your doctor before taking clindamycin to make sure it won't interfere with your medications. Those suffering from asthma, allergies, eczema, or kidney and liver disease are cautioned to seek their physician's advice before using clindamycin.
Be consistent with the application of clindamycin and try to apply it at the same time every day. If you miss an application, use the medication as soon as you remember Don't just spot treat if you have a breakout on your chin, treat your whole face. If the breakout is on your chest, treat the entire area.
Because of the alcohol in this product, It is recommended to wait 30 minutes after shaving or washing to allow the skin time to calm before applying clindamycin. This should help with irritation and reduce reactions.
Unfortunately, clindamycin is an antibacterial antibiotic and although it can help reduce instances of acne, it probably won't help with scarring. Consult your dermatologist for the best advice regarding acne scarring and how you can treat it.
As with all medications and especially considering clindamycin is a prescription medication, sharing it with others is not advised. Considering that the medication is prescribed specifically for you and your condition, it may not be appropriate for someone else to use and can cause undue harm. It is best to consult with a physician or dermatologist for the best advice to treat your preteen's acne.
Alvogen injectable generic products including clindamycin are being marketed under the brand, Almaject Inc., as of October 1, 2019. The NDC numbers for these products have changed.Baxter has clindamycin injection on shortage due to manufacturing delays.Pfizer has clindamycin injection on shortage due to manufacturing delays.Sagent did not provide a reason for the shortage.Sandoz did not provide a reason for the shortage.
Almaject has clindamycin phosphate 150 mg/mL 2 mL, 4 mL, and 6 mL vials and 60 mL bulk vials on back order and the company cannot estimate a release date.Baxter has all clindamycin premixes on a limited allocation.Pfizer has Cleocin 150 mg/mL 2 mL, 4 mL, and 6 mL vials on back order and the company estimates a release date of April 2023. The 60 mL vials are on back order and the company estimates a release date of July 2023.Sagent has clindamycin phosphate 150 mg/mL 2 mL, 4 mL, 6 mL, and 60 mL vials on back order and the company cannot estimate a release date.Sandoz has clindamycin 300 mg/50 mL, 600 mg/50 mL, and 900 mg/50 mL premixed bags on back order and the company estimates a release date of April 2023.
Acne vulgaris is a common dermatologic problem which could be treated with systemic or topical drugs. More importantly the combination therapy of topical clindamycin and tretinoin is more beneficial for the treatment of mild to moderate stages of acne vulgaris .
There are some reported articles in the literature for the determination of clindamycin [3-8] or tretinoin [9,10] alone or via the combination of the two drugs  by HPLC and gas chromatography in bulk or in pharmaceutical dosage form. HPLC method has been used in the USP35- NF30 for determination of clindamycin phosphate and tretinoin in separate gel dosage form but no simultaneous method is reported . The literature survey revealed that although there were some spectrophotometric methods for the determination of clindamycin [13,14] or tretinoin [15,16] alone, no validated spectrophotometric method for simultaneous determination of clindamycin and tretinoin was reported. The spectrophotometric technique is a highly preferable method for routine analysis due to its simplicity and economical advantages. Since the spectrophotometric quantitative analysis of two or more compounds with overlapping spectra will likely prove difficult, thus the derivative spectrophotometry is a fairly useful method for analysis of a multi-compound mixture.
To give a clear picture, the absorption spectra of clindamycin phosphate and tretinoin are shown in Figure 2 where the zero-order spectra demonstrated a marked overlapping. As a result, simultaneous determination of two drugs will not be possible by direct measurement of absorbance signals. The first to fourth order derivative spectra of those solutions were obtained in the same range at different Δλ values.
Clindamycin phosphate vaginal cream 2%, is a semi-solid, white cream, which contains 2% clindamycin phosphate, USP, at a concentration equivalent to 20 mg clindamycin per gram. The pH of the cream is between 3.0 and 6.0. The cream also contains benzyl alcohol, cetostearyl alcohol, mixed fatty acid esters, mineral oil, polysorbate 60, propylene glycol, purified water, sorbitan monostearate, and stearic acid.
The use of clindamycin phosphate vaginal cream 2% may result in the overgrowth of nonsusceptible organisms in the vagina. In clinical studies involving 600 non-pregnant women who received treatment for 3 days, Candida albicans was detected, either symptomatically or by culture, in 8.8% of patients. In 9% of the patients, vaginitis was recorded. In clinical studies involving 1325 non-pregnant women who received treatment for 7 days, Candida albicans was detected, either symptomatically or by culture, in 10.5% of patients. Vaginitis was recorded in 10.7% of the patients. In 180 pregnant women who received treatment for 7 days, Candida albicans was detected, either symptomatically or by culture, in 13.3% of patients. In 7.2% of the patients, vaginitis was recorded. Candida albicans, as reported here, includes the terms: vaginal moniliasis and moniliasis (body as a whole). Vaginitis includes the terms: vulvovaginal disorder, vulvovaginitis, vaginal discharge, trichomonal vaginitis, and vaginitis.
The patient should also be advised that this cream contains mineral oil that may weaken latex or rubber products such as condoms or vaginal contraceptive diaphragms. Therefore, use of such products within 72 hours following treatment with clindamycin phosphate vaginal cream 2%, is not recommended.
Clindamycin phosphate vaginal cream 2% has been studied in pregnant women during the second trimester. In women treated for seven days, abnormal labor was reported in 1.1% of patients who received clindamycin vaginal cream 2% compared with 0.5% of patients who received placebo.
Reproduction studies have been performed in rats and mice using oral and parenteral doses of clindamycin up to 600 mg/kg/day (62 and 25 times, respectively, the maximum human exposure based on body surface area) and have revealed no evidence of harm to the fetus due to clindamycin. Cleft palates were observed in fetuses from one mouse strain treated intraperitoneally with clindamycin at 200 mg/kg/day (about 10 times the recommended dose based on body surface area conversions). Since this effect was not observed in other mouse strains or in other species, the effect may be strain specific.
Clindamycin has the potential to cause adverse effects on the breast-fed infant's gastrointestinal flora. If clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. Monitor the breast-fed infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for clindamycin and any potential adverse effects on the breast-fed child from clindamycin or from the underlying maternal condition. 59ce067264